Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis

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Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.

Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis. The growth of hepatic cancer cells (HepG2, Huh7 and SK-Hep1) was inhibited by deguelin in a dose-de...

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Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

Angiogenesis plays a crucial role in the development of human hepatocellular carcinoma (HCC). In the present study, we found a natural compound, deguelin, has a profound anti-angiogenesis effect on HCC. Deguelin suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in...

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Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.

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ژورنال

عنوان ژورنال: Oncology Reports

سال: 2008

ISSN: 1021-335X,1791-2431

DOI: 10.3892/or.20.1.129